Maximization of Non-Monotone Submodular Functions

A litany of questions from a wide variety of scientific disciplines can be cast as non-monotone submodular maximization problems. Since this class of problems includes max-cut, it is NP-hard. Thus, general purpose algorithms for the class tend to be approximation algorithms. For unconstrained problem instances, one recent innovation in this vein includes an algorithm of Buchbinder et al. (2012) that guarantees a ½ - approximation to the maximum. Building on this, for problems subject to cardinality constraints, Buchbinderet al. (2014) o_er guarantees in the range [0:356; ½ + o(1)]. Earlier work has the best approximation factors for more complex constraints and settings. For constraints that can be characterized as a solvable polytope, Chekuri et al. (2011) provide guarantees. For the online secretary setting, Gupta et al. (2010) provide guarantees. In sum, the current body of work on non-monotone submodular maximization lays strong foundations. However, there remains ample room for future algorithm development

Approximate Inference for Determinantal Point Processes

In this thesis we explore a probabilistic model that is well-suited to a variety of subset selection tasks: the determinantal point process (DPP). DPPs were originally developed in the physics community to describe the repulsive interactions of fermions. More recently, they have been applied to machine learning problems such as search diversification and document summarization, which can be cast as subset selection tasks. A challenge, however, is scaling such DPP-based methods to the size of the datasets of interest to this community, and developing approximations for DPP inference tasks whose exact computation is prohibitively expensive. A DPP defines a probability distribution over all subsets of a ground set of items. Consider the inference tasks common to probabilistic models, which include normalizing, marginalizing, conditioning, sampling, estimating the mode, and maximizing likelihood. For DPPs, exactly computing the quantities necessary for the first four of these tasks requires time cubic in the number of items or features of the items. In this thesis, we propose a means of making these four tasks tractable even in the realm where the number of items and the number of features is large. Specifically, we analyze the impact of randomly projecting the features down to a lower-dimensional space and show that the variational distance between the resulting DPP and the original is bounded. In addition to expanding the circumstances in which these first four tasks are tractable, we also tackle the other two tasks, the first of which is known to be NP-hard (with no PTAS) and the second of which is conjectured to be NP-hard. For mode estimation, we build on submodular maximization techniques to develop an algorithm with a multiplicative approximation guarantee. For likelihood maximization, we exploit the generative process associated with DPP sampling to derive an expectation-maximization (EM) algorithm. We experimentally verify the practicality of all the techniques that we develop, testing them on applications such as news and research summarization, political candidate comparison, and product recommendation

Posterior Regularization for Structured Latent Varaible Models

We present posterior regularization, a probabilistic framework for structured, weakly supervised learning. Our framework efficiently incorporates indirect supervision via constraints on posterior distributions of probabilistic models with latent variables. Posterior regularization separates model complexity from the complexity of structural constraints it is desired to satisfy. By directly imposing decomposable regularization on the posterior moments of latent variables during learning, we retain the computational efficiency of the unconstrained model while ensuring desired constraints hold in expectation. We present an efficient algorithm for learning with posterior regularization and illustrate its versatility on a diverse set of structural constraints such as bijectivity, symmetry and group sparsity in several large scale experiments, including multi-view learning, cross-lingual dependency grammar induction, unsupervised part-of-speech induction, and bitext word alignment

The future of medical diagnostics: Review paper

While histopathology of excised tissue remains the gold standard for diagnosis, several new, non-invasive diagnostic techniques are being developed. They rely on physical and biochemical changes that precede and mirror malignant change within tissue. The basic principle involves simple optical techniques of tissue interrogation. Their accuracy, expressed as sensitivity and specificity, are reported in a number of studies suggests that they have a potential for cost effective, real-time, in situ diagnosis. We review the Third Scientific Meeting of the Head and Neck Optical Diagnostics Society held in Congress Innsbruck, Innsbruck, Austria on the 11th May 2011. For the first time the HNODS Annual Scientific Meeting was held in association with the International Photodynamic Association (IPA) and the European Platform for Photodynamic Medicine (EPPM). The aim was to enhance the interdisciplinary aspects of optical diagnostics and other photodynamic applications. The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions. © 2011 Jerjes et al; licensee BioMed Central Ltd